|
KMID : 0380620190510050499
|
|
Korean Journal of Food Science and Technology
2019 Volume.51 No. 5 p.499 ~ p.502
|
|
|
Effects of selected phytochemicals and fruit extracts on Poly(ADP-ribose) polymerase (PARP) activity induced by H2O2 in MCF-7 breast cancer cells
|
|
Yoon Hyun-Geun
|
|
|
Abstract
|
|
|
|
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which is activated in response to DNA damage, and which mediates DNA repair. PARP inhibitors can be used to reduce resistance of cancer cells to anticancer treatments. The objective of this study was to investigate the effects of selected phytochemicals and fruit extracts on PARP activation in MCF-7 breast cancer cells subjected to oxidative stress. Pre-incubation with epigallocatechin gallate (EGCG), apple extract (AE), cranberry extract (CE), or grape extract (GE) for 2 hours at test concentrations reduced PARP activity induced upon treatment with hydrogen peroxide in a dose-dependent manner (p<0.05). GE was found to be the most efficient PARP inhibitor among the fruit extracts examined. These results suggest that phytochemicals of fruit extracts might be used as PARP inhibitors in order to assist anticancer agents.
|
|
|
KEYWORD
|
|
|
PARP inhibitor, phytochemical, EGCG, fruit extract
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|